abstract：:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in indivi...

journal_title：Environmental toxicology and pharmacology

authors： Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

更新日期：2015-01-01 00:00:00

abstract：:In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically examining the epidermal thic...

journal_title：Environmental toxicology and pharmacology

authors： Im AR,Song JH,Lee MY,Chae S

更新日期：2015-01-01 00:00:00

abstract：:Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activati...

journal_title：Environmental toxicology and pharmacology

authors： Tanuja Yadav,Mishra S,Das S,Aggarwal S,Rani V

更新日期：2015-01-01 00:00:00

abstract：:To investigate the regulated role of IL-1β in initiating and maintaining inflammation, PMA-differentiated THP-1 macrophages were exposed to two micro-sized crystalline silica particles (Si3-5μm and Si1μm) from 3h to 24h, respectively. Cytotoxicity and inflammatory cytokines (IL-1β, TNF-α and IL-6) expressions measured...

journal_title：Environmental toxicology and pharmacology

authors： Zhou T,Cui X,Zhou Y,Guo J,Rong Y,Chen W

更新日期：2015-01-01 00:00:00

abstract：:The disposition kinetics study of cefquinome was conducted following single intravenous (IV) administration of 2mg/kg bodyweight in buffalo calves after oral subchronic exposure to flubendiamide and to determine the in vitro plasma protein binding of cefquinome. Plasma concentrations of cefquinome were analyzed using ...

journal_title：Environmental toxicology and pharmacology

authors： Venkatachalam D,Dumka VK

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to investigate the toxic effects induced by benzo[a]pyrene (BaP). In the present study, juvenile white shrimp Litopenaeus vannamei were exposed to BaP for 21 days at four different concentrations as 0, 0.03, 0.3 and 3μg/L. Detoxification system parameters, transcription of metabolism-rela...

journal_title：Environmental toxicology and pharmacology

authors： Ren X,Pan L,Wang L

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique. The -3860A and -729T allele we...

journal_title：Environmental toxicology and pharmacology

authors： Szalai R,Magyari L,Matyas P,Duga B,Banfai Z,Szabo A,Kovesdi E,Melegh B

更新日期：2014-11-01 00:00:00

abstract：:This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...

journal_title：Environmental toxicology and pharmacology

authors： Guo W,Shi X,Wang W,Zhang W,Li J

更新日期：2014-11-01 00:00:00

abstract：:This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...

journal_title：Environmental toxicology and pharmacology

authors： Jiang P,Sheng YC,Chen YH,Ji LL,Wang ZT

更新日期：2014-11-01 00:00:00

abstract：:The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Ther...

journal_title：Environmental toxicology and pharmacology

authors： Janusch F,Scherz G,Mohring SA,Hamscher G

更新日期：2014-11-01 00:00:00

abstract：:The liposoluble constituents of leaves (LCL) and stem barks (LCSB) from Acanthopanax evodiaefolius Franch were extracted by Herbal Blitzkrieg Extractor (HBE), and their chemical composition was analyzed by GC-MS. 18 compounds were identified, representing 71.98% of LCL, while 35 compounds were identified, accounting f...

journal_title：Environmental toxicology and pharmacology

authors： Huang WC,Li Z,Li XJ,Gong LM,Liu XQ,Kwon OK,Ye HX,Lee HK

更新日期：2014-09-01 00:00:00

abstract：:Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

journal_title：Environmental toxicology and pharmacology

authors： Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

更新日期：2014-09-01 00:00:00

abstract：:The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigo...

journal_title：Environmental toxicology and pharmacology

authors： Khazaeli P,Sharifi I,Talebian E,Heravi G,Moazeni E,Mostafavi M

更新日期：2014-07-01 00:00:00

abstract：:Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor inc...

journal_title：Environmental toxicology and pharmacology

authors： Zhang W,Liu K,Chen L,Chen L,Lin K,Fu R

更新日期：2014-07-01 00:00:00

abstract：:Endocrine disrupting chemicals have raised public concern, since their effects have been found to interfere with the physiological systems of various organisms, especially during critical stage of development and reproduction. Endosulfan and malathion, pesticides widely used for agricultural purposes, have been known ...

journal_title：Environmental toxicology and pharmacology

authors： Laldinsangi C,Vijayaprasadarao K,Rajakumar A,Murugananthkumar R,Prathibha Y,Sudhakumari CC,Mamta SK,Dutta-Gupta A,Senthilkumaran B

更新日期：2014-05-01 00:00:00

abstract：:Uzuncayir Dam Lake is one of the most important water bodies in Tunceli. It is polluted by domestic wastewaters together with natural contamination and pesticides, which have had cumulatively negative effects. This study analyzes the effects of pollution by using the fish species, Capoeta umbla as a sentinel species, ...

journal_title：Environmental toxicology and pharmacology

authors： Yildirim NC,Yildirim N,Danabas D,Danabas S

更新日期：2014-05-01 00:00:00

abstract：:Chronic inflammation occurs systematically in the central nervous system during ageing, it has been shown that neuroinflammation plays an important role in the pathogenesis of many neurodegenerative disorders. Aspirin, a nonselective COX inhibitor, as well as ascorbic acid, has been purported to protect cerebral tissu...

journal_title：Environmental toxicology and pharmacology

authors： Kara Y,Doguc DK,Kulac E,Gultekin F

更新日期：2014-05-01 00:00:00

abstract：:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...

journal_title：Environmental toxicology and pharmacology

authors： Kasperczyk S,Dobrakowski M,Kasperczyk A,Machnik G,Birkner E

更新日期：2014-03-01 00:00:00

abstract：:Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...

journal_title：Environmental toxicology and pharmacology

authors： Wang W,Chen QF,Li QB,Wu YB,Chen K,Chen B,Wen JM

更新日期：2014-03-01 00:00:00

abstract：UNLABELLED:The studies aimed at evaluation of cigarette smoke effect on heart rate turbulence (HRT) in patients with arterial hypertension (AH). 223 consecutive individuals were qualified to the studies. The following groups of patients not suffering from other disease which may affect HRT were distinguished: 1--patien...

journal_title：Environmental toxicology and pharmacology

authors： Gać P,Sobieszczańska M

更新日期：2014-03-01 00:00:00

abstract：:In this study, the toxic effect of cadmium on extracellular Na(+), K(+), and Ca(2+) in the gill and small intestine of goldfish Carassius auratus was determined with the technique of ion chromatograph. Two-way ANOVA indicated that the two factors (Cd(2+) treatment and time) and the interaction factor had significant e...

journal_title：Environmental toxicology and pharmacology

authors： Liu D,Guo H,Chen Z,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pr...

journal_title：Environmental toxicology and pharmacology

authors： Hou H,Zhou R,Li A,Li C,Li Q,Liu J,Jiang B

更新日期：2014-03-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric c...

journal_title：Environmental toxicology and pharmacology

authors： Pohanka M

更新日期：2014-01-01 00:00:00

abstract：:The free radicals within the body, produced by metabolic activities or derived from environmental sources are relatively related to hepatoxicity. Since heavy metals including iron have the ability to produce free radicals, the liver glutathione system neutralizes them to protect cells against any damage. The objective...

journal_title：Environmental toxicology and pharmacology

authors： Budak H,Gonul N,Ceylan H,Kocpinar EF

更新日期：2014-01-01 00:00:00

abstract：:Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

journal_title：Environmental toxicology and pharmacology

authors： Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

更新日期：2014-01-01 00:00:00

abstract：:Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals (alcohol), xenobiotics (carbon tetrachloride, chlorinated hydrocarbons and gases CO₂ and O₂) anticancer (azathioprine, doxorubicin, cisplatin)...

journal_title：Environmental toxicology and pharmacology

authors： Ingawale DK,Mandlik SK,Naik SR

更新日期：2014-01-01 00:00:00

abstract：:The effect of neonatal manganese (Mn) exposure in a 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease was investigated. Pregnant Wistar rats were given drinking water with 10,000 ppm of Manganese (MnCl₂.4H₂O) from the time of conception until weaning on the 21st day after delivery. Control rats consumed tap ...

journal_title：Environmental toxicology and pharmacology

authors： Szkilnik R,Brus R,Malinowska-Borowska J,Nowak D,Waliczek M,Kostrzewa RM,Nowak P

更新日期：2014-01-01 00:00:00

abstract：:The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injecti...

journal_title：Environmental toxicology and pharmacology

authors： Vanitha P,Uma C,Suganya N,Bhakkiyalakshmi E,Suriyanarayanan S,Gunasekaran P,Sivasubramanian S,Ramkumar KM

更新日期：2014-01-01 00:00:00

abstract：:Hepatotoxicity is the most serious adverse effect related to tuberculosis treatment which interrupts the successful completion of tuberculosis treatment. The purpose of this study was to assess therapeutic effect of thymoquinone (TQ) against anti-tuberculosis drugs (ATD) induced liver damage. Rats were treated with AT...

journal_title：Environmental toxicology and pharmacology

authors： Jaswal A,Sinha N,Bhadauria M,Shrivastava S,Shukla S

更新日期：2013-11-01 00:00:00

abstract：:Cadmium (Cd) is a major pollutant of environment. It can be fatal to human. In spite of bulk of research and literatures, the mechanism of a fatality against human is still not understood completely. Toxic and carcinogenic effects of Cd in rodents and humans are well known. However, effects of Cd on induction of apopt...

journal_title：Environmental toxicology and pharmacology

authors： Al-Assaf AH,Alqahtani AM,Alshatwi AA,Syed NA,Shafi G,Hasan TN

更新日期：2013-11-01 00:00:00

abstract：:Arsenic (As) widely studied for its effects as a neurotoxicant. The present study was designed to evaluate the protective effect of calcium, zinc or monoisoamyl dimercaptosuccinic acid (MiADMSA), either individually or in combination on As induced oxidative stress and apoptosis in brain regions (cerebral cortex, hippo...

journal_title：Environmental toxicology and pharmacology

authors： Kadeyala PK,Sannadi S,Gottipolu RR

更新日期：2013-11-01 00:00:00

abstract：:Pyrazolo[1,5-a]indole derivatives, a new type of topoisomerase (topo) inhibitor, demonstrate a broad spectrum of antitumor activities. However, the mechanism underlying the induced cytotoxicity remains unclear. In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast can...

journal_title：Environmental toxicology and pharmacology

authors： Ji YY,Zhu YM,Wang JW

更新日期：2013-11-01 00:00:00

abstract：:Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, th...

journal_title：Environmental toxicology and pharmacology

authors： Dodd DE,Layko DK,Cantwell KE,Willson GA,Thomas RS

更新日期：2013-11-01 00:00:00

abstract：:The hypothesis that temperature variation is able to modify the chronic toxicity of the antibiotic florfenicol (FLO) to Daphnia magna was tested in the present study. Twenty-one day laboratory bioassays were carried out at 20 and 25 °C. FLO concentrations and its potential decay during the assays were checked by spect...

journal_title：Environmental toxicology and pharmacology

authors： Martins A,Guimarães L,Guilhermino L

更新日期：2013-11-01 00:00:00

abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

journal_title：Environmental toxicology and pharmacology

authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

更新日期：2013-11-01 00:00:00

abstract：:Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver. Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and other active components and have high antioxidant capacities. We investigated the effect of BB pretreatment...

journal_title：Environmental toxicology and pharmacology

authors： Bingül İ,Başaran-Küçükgergin C,Tekkeşin MS,Olgaç V,Doğru-Abbasoğlu S,Uysal M

更新日期：2013-09-01 00:00:00

abstract：:The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR...

journal_title：Environmental toxicology and pharmacology

authors： Mladenović D,Ninković M,Aleksić V,Šljivančanin T,Vučević D,Todorović V,Stanković M,Stanojlović O,Radosavljević T

更新日期：2013-09-01 00:00:00

abstract：:Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-beta-d-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid co...

journal_title：Environmental toxicology and pharmacology

authors： Zhang YN,Song M,Ng TB,Zhao L,Liu F

更新日期：2013-09-01 00:00:00

abstract：:The epothilones, a new class of microtubule-targeting agents, seem to be a very promising alternative to the current strategy of cancer treatment. We have analyzed the aspects of epothilone B (Epo B) on cellular metabolism of tumor (OV-90) and normal (MM 14) ovarian cells. The observed effects were compared with those...

journal_title：Environmental toxicology and pharmacology

authors： Rogalska A,Szula E,Gajek A,Marczak A,Jóźwiak Z

更新日期：2013-09-01 00:00:00

abstract：:Metabolic activity, particularly conjugation, was examined in fish by analyzing pyrene (a four-ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry (MS) system, and kinetic analysis of conjugation enzymes. Fourteen f...

journal_title：Environmental toxicology and pharmacology

authors： Ikenaka Y,Oguri M,Saengtienchai A,Nakayama SMM,Ijiri S,Ishizuka M

更新日期：2013-09-01 00:00:00